Automated assessment of functional lung imaging with 68Ga-ventilation/perfusion PET/CT using iterative histogram analysis
نویسندگان
چکیده
Abstract Purpose Functional lung mapping from Ga 68 -ventilation/perfusion (V/Q) PET/CT, which has been shown to correlate with pulmonary function tests (PFTs), may be beneficial in a number of clinical applications where sparing regions high is interest. Regions clumping the proximal airways patients disease can result areas focal intense activity and artefact ventilation imaging. These artefacts even shine through subsequent perfusion images create challenge for quantitative analysis PET We aimed develop an automated algorithm that interprets uptake histogram calculate peak value more representative global volume. Methods Sixty-six recruited prospective trial underwent both V/Q PET/CT imaging PFT before treatment. were normalised using iterative technique account tracer hotspots prior threshold-based delineation varying values. Pearson’s correlation between fractional score was calculated ventilation, perfusion, matched volumes at threshold Results For all functional thresholds, only FEV1/FVC yielded reasonable correlations image-based range 10–30% adapted provided define volume correlated ( r = 0.54–0.61). imaging, similar observed 0.51–0.56) 20–60% threshold. Matched closely linked 15–35% yielding 0.55–0.58). Conclusions Histogram normalisation implemented determine presence Ga-68 allowing standardisation reporting.
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ژورنال
عنوان ژورنال: EJNMMI Physics
سال: 2021
ISSN: ['2197-7364']
DOI: https://doi.org/10.1186/s40658-021-00375-6